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    The state-of-the-art services the platform carry out include synthetic molecules characterization, protein identification/quantitation, protein-protein interaction, and protein structure, dynamics analysis, Glycosylation analysis, etc.

    平台可以提供合成小分子的结构分析,蛋白(组)的定性、定量分析,蛋白-蛋白/蛋白-小分子相互作用分析、蛋白动态构象分析,糖基化分析等等服务。


     ?Protein Identification service. The service identify proteins from solutions or gel bands.

    蛋白鉴定分析:可覆盖胶条、溶液、beads等多种样品形式


     ?Quantitative proteomics analysis. The service measure relative protein abundance using Label free, SILAC, iTRAQ and TMT techniques. We accept samples from cells, tissues and serum.

    定量蛋白组学分析:包括非标记定量分析w88优德体育下载、同位素标记定量分析(SILAC, iTRAQ and TMT)。样品类型可以是细胞w88优德体育下载、组织等。


     ?Protein Structure Analysis. Both chemical crosslinking MS and HDX-MS techniques are employed to study dynamic protein conformation, protein-protein interactions, and protein-small molecular interactions.

    蛋白结构分析:包括交联质谱(xlink-ms)和氢氘交换质谱(HDX-MS)技术,分析蛋白-蛋白/小分子的相互作用。


    ?Metabolites characterization. We provide identification services for metabolites mixtures and quantification services for target metabolites.

    代谢组学分析:定性、定量代谢组学质谱分析


     ?Synthetic molecules characterization. We provide both identification and quantification services for synthetic molecules and oligonucleotides by using LC-MS, GCMS and NMR techniques.

    化学小分子分析:含量,分子量w88优德体育下载、结构测定等


    ?Antibody characterization services. 

    抗体分析

    1.Accurate mass determination for mAb, ADC, biosimilars, fusion proteins分子量测定

    2.Disulfide bond mapping二硫键分析

    3.mAb denovo sequencing氨基酸序列分析

    4.PTM mapping including glycosylation翻译后修饰分析

    5.Aggregation, purity and charge variants characterization 纯度、电荷异质性分析等


    Table 1. Functions of SIAIS Analytical Platform


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